Endocrine Abstracts

Isoflavones are a subgroup of phytoestrogens and have a chemical structure similar to oestrogen, leading to concerns regarding possible adverse effects of isoflavones in men. Testosterone levels in men with type 2 diabetes mellitus (T2DM) are lower.Materials and methods: A randomised double-blind, parallel study was undertaken with 200 men with T2DM, of median age of 50 years (25th/75th centiles; 50, 55) years with a total testosterone level ≤12 nm...

: In patients with subclinical hypothyroidism, soy protein and isoflavone combination has been shown to increase the risk of developing overt hypothyroidism; however, it is unclear if soy affects thyroid function in those without existing thyroid compromise.Materials and methods: Two double blind randomised trials were undertaken in which thyroid function was performed routinely at the beginning and end as a secondary end point. In both trials soy protei...

Context: Soy phytoestrogens are suggested to have an adverse effect on thyroid function but the contribution to this by soy protein alone when free from isoflavones is unknown.Objective: The primary aim was to determine the effect of isoflavone free soy protein supplementation on thyroid function, with a secondary aim of assessing the effects on cardiovascular risk indices in patients with subclinical hypothyroidism.Design and sett...

Importance: The major factor contributing to the high incidence of osteoporosis in older women is the reduction in estrogen synthesis. Isoflavones have a similar structure to 17-β estradiol and can act as selective estrogen receptor modulators.Objective: To determine the safety and effect of soy isoflavones on bone during early menopause.Design: Parallel, double blind, study.Setting: Secondary care resea...

Soy phytoestrogens (PE) have been shown to improve insulin resistance and lipids but may adversely affect thyroid function.Objective: To determine the effects of soy PE on thyroid function, insulin resistance and lipid parameters in patients with subclinical hypothyroidism.Design: A randomised, double-blind, crossover study was undertaken involving 60 patients with subclinical hypothyroidism. Patients were randomly assigned to eith...